Powerful Anti-Spot Serum with Intense Whitening Action against Hyper-Pigmentation

Age spots and dark patches on the skin are the results of the localized overproduction of melanin. CHOLLEY Phytocell Harmonizer, has been specially developed to fight the hyper-pigmentation of the skin. It uses absolutely the best, the most effective, and the safest phytobiological ingredients to achieve its exceptional performance.

Discover the exclusive features of IC-RAMP® Technology


  • Obstructs the production of melanin
  • Very intense skin whitening action
  • Slows the photo-aging process by increasing the resistance of the skin against oxidative UV stress
  • Regenerating, conditioning, and skin repairing action
  • Harmonizing and hydrating action


For best results, in the morning and evening, after thoroughly cleansing, apply CHOLLEY Phytocell Harmonizer on the hyper-pigmented areas of the face, neck, and décolleté. Use a light massage for best absorption of the product. During the day for UV protection, follow the application of CHOLLEY Phytocell Harmonizer with CHOLLEY Alpine Solar Defense – SPF 50 as a sunscreen.

For additional anti-aging and whitening action, we strongly recommend the use of CHOLLEY Clearing Ampoules, coupled with regular weekly peelings with CHOLLEY Phyto-Exfoliant Suractivée. Periodic professional exfoliations with the BIOCLEAN AHA Peeling Program are also very beneficial.


For all skin types.


Premium Anti-Spot Serum with Powerful Whitening Action against Skin Hyper-Pigmentation 
30 ml – Ref. 1006V

Based on 31 reviews
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Olha PolishchukOlha Polishchuk
18:36 25 Nov 22
I was very happy to receive my order. My skin on face started to have acne, and I was desperately searching something to cure that. Cream and mask which I ordered helped me to avoid serious problems with my skin, I am so happy that I could prevent to have disaster on my face. Definitely, it was the best cosmetics I ever used
Susanne KemperSusanne Kemper
12:34 24 Jun 22
Seeing my Geneva dermatologist for the first time in March since Covid descended and restrained travel, she was amazed at my facial appearance, my skin’s healthy radiance, its texture and vitality. Additionally my pores were improved too which after years of focus that was no longer a primary action. When I told her I started with Cholley products – eye contour and skin day care 20 months ago – which really made a difference, then I added the night care. Their Vitamin C Day care has been tops too for over 11 months; plus for the last 6 months their new repair masque. All have helped my skin’s elasticity, texture as well as appearance in spite of my time this winter from January 2 to March in the sun covering golf tournaments in Hawaii, California, Arizona. Cholley has really given me an image boost!
Benedetta TovoBenedetta Tovo
11:32 03 Feb 22
Best skincare products ever and amazing costumer service. I definitely recommend them.
Vera Irene BekinVera Irene Bekin
16:10 02 Feb 22
Marvellous products and excellent service in solving delivery difficulties!
Hi, dear colleagues!My name is Alexandr Borodco, I’m a plastic surgeon from Kyiv, Ukraine!For about 20 years now I have been practicing chemical peeling, and throughout this period my main issue has always been prolonged redness of the skin! However, after I started using Cholley Skin Repair Complex, I no longer have this issue, so I am very thankful to Cholley laboratory and a whole team! I wish to the company even more great success and many more brilliant ideas!
I'm a dermatologist from Ukraine 🇺🇦I would like to thank Cholley for such a wonderful product! I prescribe beauty preparations to my patients, and I'm very happy that both I and they see the promised results. I've never had any adverse skin reactions from my patients. The products perform their functions gently and carefully. Incredible textures and flavors! It is a great pleasure to work with Cholley!
19:27 13 Dec 21
We have been selling Cholley's exclusive products for years and are very satisfied and receive very positive results from enthusiastic customers.
Nedyalko BakardzhievNedyalko Bakardzhiev
18:18 10 Dec 21
I am the distributor for Bulgaria and for a long time I have been looking for a brand to offer to my customers with the requirement to be on a phyto basis, to be different from other brands, to combine innovative biotechnology with uncompromising quality, and of course to bring amazing results. Well, I found it at METHODE CHOLLEY and I am extremely happy to have the opportunity to distribute a brand of the highest class.Every professional and client who has touched Methode Cholley's products remain very impressed by the delicate textures, elegant aroma and amazing results.


CHOLLEY Phytocell Harmonizer is exceptionally rich in skin whitening active ingredients including Alpha Arbutin, Lepidium Sativum Sprout Extract, and stem cell extracts of Vitis Vinifera (grape) and Azelamide MEA.
The combined effect of these ingredients is further enhanced by the natural extracts of licorice and cucumber. Hence, CHOLLEY Phytocell Harmonizer Anti-Spot Serum drastically lowers the melanin content of the hyper-pigmented skin, for fast and satisfying results. It also protects the skin against photo-aging and oxidizing UV stress.


CHOLLEY Phytocell Harmonizer anti-spot serum contains the stem cell extract of Vitis Vinifera, a rare variety of Gamay grape that is highly tolerant to UV radiation. This special variety is known for its red flesh and juice, due to an extremely high content of anthocyanin. As power antioxidants, anthocyanins are excellent free radical scavengers and act as natural sunscreens.

Anti spot serum - CHOLLEY

Vitis Vinifera stem cells generate special epigenetic factors that:

  • Protect human skin against the UV stress
  • Preserve the regenerative potency of epidermal stem cells
  • Increase the tolerance of skin to UV radiation


Results After 2 Weeks


Anti spot serum - CHOLLEY

  • Profound reduction of intensity of Age spots

  • Significant visible differences between treated and untreated area for all tested volunteers

* The test was conducted by an independent laboratory on 20 volunteers of either sex, having at least two hyperchromic spots on the face or on the dorsal part of the hands, average age 62.2 years.


Excellent Whitening Effects with increased values of ITA° and L* between treated and untreated area.


“CHOLLEY Phytocell Harmonizer can be considered an Effective Product
against Age Spots
and the Dark Patches on the skin”


Hyper-pigmentation can cause age spots or dark patches due to increased or irregular production of melanin. A skin trauma or acne scars can also result in hyper-pigmentation.

Age spots on an elderly hand

Postpregnancy melasma

Hyper-pigmentation of the skin is a difficult problem, and its proper care requires a very high-quality product and consistency in use.

For this purpose, CHOLLEY Phytocell Harmonizer anti spot serum has been developed as a Super Premium  product using absolutely the best, the most effective, and the safest ingredients available.

CHOLLEY Phytocell Harmonizer utilizes a double-pronged approach by:

1. Obstructing the production of melanin by blocking the attachment of α-MSH to melanocytes

2. Arresting the maturation of melanin and its darkening by impeding the activity of the tyrosinase hormone.


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