Powerful Anti-Spot Serum with Intense Whitening Action against Hyper-Pigmentation

Age spots and dark patches on the skin are the results of the localized overproduction of melanin. CHOLLEY Phytocell Harmonizer, has been specially developed to fight the hyper-pigmentation of the skin. It uses absolutely the best, the most effective, and the safest phytobiological ingredients to achieve its exceptional performance.

Discover the exclusive features of IC-RAMP® Technology
  • Obstructs the production of melanin
  • Very intense skin whitening action
  • Slows the photo-aging process by increasing the resistance of the skin against oxidative UV stress
  • Regenerating, conditioning, and skin repairing action
  • Harmonizing and hydrating action

For best results, in the morning and evening, after thoroughly cleansing, apply CHOLLEY Phytocell Harmonizer on the hyper-pigmented areas of the face, neck, and décolleté. Use a light massage for best absorption of the product. During the day for UV protection, follow the application of CHOLLEY Phytocell Harmonizer with CHOLLEY Alpine Solar Defense – SPF 50 as a sunscreen.

For additional anti-aging and whitening action, we strongly recommend the use of CHOLLEY Clearing Ampoules, coupled with regular weekly peelings with CHOLLEY Phyto-Exfoliant Suractivée. Periodic professional exfoliations with the BIOCLEAN AHA Peeling Program are also very beneficial.

For all skin types.

Premium Anti-Spot Serum with Powerful Whitening Action against Skin Hyper-Pigmentation 
30 ml – Ref. 1006V


12:12 25 Apr 24
I discovered this brand in a Parisian beauty institute. I ordered directly from their site.Great products, received quickly, carefully packaged with lots of samples.I recommend this high quality Swiss brand.
Rosa Ferrer TorresRosa Ferrer Torres
19:22 24 Apr 24
Super recommended!!!
Алина БабичАлина Бабич
03:40 02 Mar 24
I started using Cholley products 4 months ago. I’m extremely satisfied with the whitening and anti-wrinkle products. I can say that Phytocell line works absolute magic for tired and dull skin which is my case. I frequently fly and Phytocell creams help rejuvenate my skin immediately. Also I have noticed significant anti-wrinkle effect with Eye contour cream and Phytocell booster.Another great product is Professional AHA Mask that I use once in 10 days to exfoliate. It immediately brightens my skin and gives this silky sensation that I enjoy.I also tired whitening products such as Whitintense serum, clearing mask and Anti-Spot Ampoules. I observed that my pigmentation reduced and complexion brightened.I would definitely recommend Cholley. It is the quality of products that will be coming back for.
Esther GentiliEsther Gentili
00:45 28 Feb 24
I have been using this cosmetics line for a year now and I must say it is helping me a lot with my acne problems. It leaves my face smooth , brighter and glowing effect. I guess I will never turn back !!!
juan valerojuan valero
21:17 27 Feb 24
Nadia CiprianiNadia Cipriani
20:16 27 Feb 24
I have been using the doux peeling from the Bioregene line for years. Fantastic!
Silvia TschuorSilvia Tschuor
18:51 27 Feb 24
Thanks for your professionalism
Cholley has been the best cosmetics brand on the market for us for years. The quality is excellent and the product does what it promises. It's an innovative brand that really tackles the skin problems!Recently we were able to attend the CHOLLEY seminar & symposium 2023. Which have been very interesting and informative! Many thanks to Madam Cholley, Rick Paydar, Matteo and team. It was an educational and inspiring journey.
Nikolaos KapaNikolaos Kapa
09:24 10 Dec 23
Light, smooth and you definitely feel that it works miracles. Helped me a lot with my rosacea.
When I started using Cholley products, my skin said to me, "Thank you very much 🙏." We receive similar feedback from our patients:My skin absorbs the product so easily, as if it's drinking it. There are no traces of stickiness or greasiness after applying the cream.After using Cholley AHA 707v, the skin acquired an even tone, like after a course of peels.Plastic surgeons and laser procedure clinics achieve stunning results when using 1010v Phytobiotech Skin Repair Complex and 1011v Phytobiotech Detox Revitalizer after aggressive procedures and traumas."I've had many collagen procedures, but Cholley's collagen mask is the best," says Olya Polyakova, a popular Ukrainian singer."Perhaps Phytocell eye contour cream is the best cream I've ever used," says the owner of a network of cosmetic clinics in Ukraine.Every product from the Cholley brand is a bestseller. I wish the manufacturer great success and look forward to new products eagerly.
14:20 08 Nov 23
Top quality, Moisturizer is One of the best products I’ve ever used. Now my morning starts with a coffee and cholley moisturizer 👌🏻.
daryna kononenkodaryna kononenko
12:09 08 Nov 23
Cholley is the best thing that has ever happened to my skin!Not only they have the best products to make your skin healthy and if you start using their cosmetics now it will help you look your best in the future, the products also solve enormous amount of problems. For me personally it was the issue with post acne pigmentation. After the acne I did not have scars, but I was left with bunch of brown spots on my cheeks and all I wanted was the same tone skin. After the 3 month or daily use of Cholley products and especially S Ampules, the skin on my face developed healthy bright and the same tone color, it is shiny and elastic. At this point I do not even need to use any kind of foundation, as my cheeks have natural pink color, I have no pigmentation left and I couldn't have been more satisfied with the result. I will most definitely continue using Cholley for the rest of my life!
Agustina DarsonoAgustina Darsono
16:44 02 Nov 23
The 2023 CHOLLEY seminar was very educational and informative. We make many new friends from Mexico, Hong Kong, Netherland, Ukraine, Malaysia, and of course from Switzerland. Many thanks to Mdm Cholley Paydar, Mr. Rick Paydar, Matteo, & team. We definitely learn a lot about pre & post surgery management. Special thanks also to Prof. Dr. med. Yves Harder, Dr. Zucal Isabel, for their time and input on skin stress management and key to anti-aging. We look forward to more zoom and on-site workshops.
Olha PolishchukOlha Polishchuk
18:36 25 Nov 22
I was very happy to receive my order. My skin on face started to have acne, and I was desperately searching something to cure that. Cream and mask which I ordered helped me to avoid serious problems with my skin, I am so happy that I could prevent to have disaster on my face. Definitely, it was the best cosmetics I ever used
Susanne KemperSusanne Kemper
12:34 24 Jun 22
Seeing my Geneva dermatologist for the first time in March since Covid descended and restrained travel, she was amazed at my facial appearance, my skin’s healthy radiance, its texture and vitality. Additionally my pores were improved too which after years of focus that was no longer a primary action. When I told her I started with Cholley products – eye contour and skin day care 20 months ago – which really made a difference, then I added the night care. Their Vitamin C Day care has been tops too for over 11 months; plus for the last 6 months their new repair masque. All have helped my skin’s elasticity, texture as well as appearance in spite of my time this winter from January 2 to March in the sun covering golf tournaments in Hawaii, California, Arizona. Cholley has really given me an image boost!UPDATE November 2023....After four surgeries in 2022 and one in 2023, I'M SO THANKFUL to CHOLLEY as my face is still maintains healthy, elasticity and texture...AND LOVE THEIR NEW NECK CREME AND SERUM...A DELIGHT! Wonderful serum for the night application and then their new rich cream for day--not staining clothes even silk blouses! Amazing plus healthy skin even with all my convertible driving in summer and in California in the winters, the skin is healthier, less dry, wrinkled appearance from sun, golf, skiing, etc...I only travel with Cholley 12 months on 12...Thank you!This NEW neck cream is very unctuous but not greasy, absorbs quickly, has a lovely fragrance- superb with top results in 3 months now! The serum I use on the neck at night after cleansing the neck; it absorbs easily- no spots on my silk or cotton sleepwear either in hot summer nor now in winter. Thanks so much Chollley SA for creating these new ***** wonders for the skin and our appearance.
Benedetta TovoBenedetta Tovo
11:32 03 Feb 22
Best skincare products ever and amazing costumer service. I definitely recommend them.
Vera Irene BekinVera Irene Bekin
16:10 02 Feb 22
Marvellous products and excellent service in solving delivery difficulties!
Hi, dear colleagues!My name is Alexandr Borodco, I’m a plastic surgeon from Kyiv, Ukraine!For about 20 years now I have been practicing chemical peeling, and throughout this period my main issue has always been prolonged redness of the skin! However, after I started using Cholley Skin Repair Complex, I no longer have this issue, so I am very thankful to Cholley laboratory and a whole team! I wish to the company even more great success and many more brilliant ideas!
I'm a dermatologist from Ukraine 🇺🇦I would like to thank Cholley for such a wonderful product! I prescribe beauty preparations to my patients, and I'm very happy that both I and they see the promised results. I've never had any adverse skin reactions from my patients. The products perform their functions gently and carefully. Incredible textures and flavors! It is a great pleasure to work with Cholley!
19:27 13 Dec 21
We have been selling Cholley's exclusive products for years and are very satisfied and receive very positive results from enthusiastic customers.
Nedyalko BakardzhievNedyalko Bakardzhiev
18:18 10 Dec 21
I am the distributor for Bulgaria and for a long time I have been looking for a brand to offer to my customers with the requirement to be on a phyto basis, to be different from other brands, to combine innovative biotechnology with uncompromising quality, and of course to bring amazing results. Well, I found it at METHODE CHOLLEY and I am extremely happy to have the opportunity to distribute a brand of the highest class.Every professional and client who has touched Methode Cholley's products remain very impressed by the delicate textures, elegant aroma and amazing results.


CHOLLEY Phytocell Harmonizer is exceptionally rich in skin whitening active ingredients including Alpha Arbutin, Lepidium Sativum Sprout Extract, and stem cell extracts of Vitis Vinifera (grape) and Azelamide MEA.
The combined effect of these ingredients is further enhanced by the natural extracts of licorice and cucumber. Hence, CHOLLEY Phytocell Harmonizer Anti-Spot Serum drastically lowers the melanin content of the hyper-pigmented skin, for fast and satisfying results. It also protects the skin against photo-aging and oxidizing UV stress.


CHOLLEY Phytocell Harmonizer anti-spot serum contains the stem cell extract of Vitis Vinifera, a rare variety of Gamay grape that is highly tolerant to UV radiation. This special variety is known for its red flesh and juice, due to an extremely high content of anthocyanin. As power antioxidants, anthocyanins are excellent free radical scavengers and act as natural sunscreens.

Anti spot serum - CHOLLEY

Vitis Vinifera stem cells generate special epigenetic factors that:

Protect human skin against the UV stress

Preserve the regenerative potency of epidermal stem cells

Increase the tolerance of skin to UV radiation


Results After 2 Weeks


Anti spot serum - CHOLLEY

  • Profound reduction of intensity of Age spots

  • Significant visible differences between treated and untreated area for all tested volunteers

* The test was conducted by an independent laboratory on 20 volunteers of either sex, having at least two hyperchromic spots on the face or on the dorsal part of the hands, average age 62.2 years.


Excellent Whitening Effects with increased values of ITA° and L* between treated and untreated area.


“CHOLLEY Phytocell Harmonizer can be considered an Effective Product
against Age Spots
and the Dark Patches on the skin”


Hyper-pigmentation can cause age spots or dark patches due to increased or irregular production of melanin. A skin trauma or acne scars can also result in hyper-pigmentation.

Age spots on an elderly hand

Postpregnancy melasma

Hyper-pigmentation of the skin is a difficult problem, and its proper care requires a very high-quality product and consistency in use.

For this purpose, CHOLLEY Phytocell Harmonizer anti spot serum has been developed as a Super Premium  product using absolutely the best, the most effective, and the safest ingredients available.

CHOLLEY Phytocell Harmonizer utilizes a double-pronged approach by:

1. Obstructing the production of melanin by blocking the attachment of α-MSH to melanocytes

2. Arresting the maturation of melanin and its darkening by impeding the activity of the tyrosinase hormone.




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